تفاصيل الوثيقة نوع الوثيقة : مقال في مجلة دورية  عنوان الوثيقة : Flanking Variation Influences Rates of Stutter in Simple Repeats Flanking Variation Influences Rates of Stutter in Simple Repeats   لغة الوثيقة : الانجليزية  المستخلص : It has been posited that the longest uninterrupted stretch (LUS) of tandem repeats, as defined by the number of exactly matching repeating motif units, is a better predictor of rates of stutter than the parental allele length (PAL). While there are cases where this hypothesis is likely correct, such as the 9.3 allele in the TH01 locus, there can be situations where it may not apply as well. For example, the PAL may capture flanking indel variations while remaining insensitive to polymorphisms in the repeat, and these haplotypic changes may impact the stutter rate. To address this, rates of stutter were contrasted against the LUS as well as the PAL on different flanking haplotypic backgrounds. This study shows that rates of stutter can vary substantially depending on the flanking haplotype, and while there are cases where the LUS is a better predictor of stutter than the PAL, examples to the contrary are apparent in commonly assayed forensic markers. Further, flanking variation that is 7 bp from the repeat region can impact rates of stutter. These findings suggest that non-proximal effects, such as DNA secondary structure, may be impacting the rates of stutter in common forensic short tandem repeat markers.  ردمد : 2073-4425  اسم الدورية : Genes  المجلد : 8  العدد : 11  سنة النشر : 1438 هـ 2017 م  نوع المقالة : مقالة علمية  تاريخ الاضافة على الموقع : Wednesday, June 26, 2019  الباحثون اسم الباحث (عربي) اسم الباحث (انجليزي) نوع الباحث المرتبة العلمية البريد الالكتروني August E. Woerner Woerner, August E. باحث رئيسي دكتوراه August.Woerner@unthsc.edu Jonathan L. King King, Jonathan L. باحث دكتوراه   Bruce Budowle Budowle, Bruce باحث رئيسي دكتوراه Bruce.Budowle@unthsc.edu الملفات اسم الملف النوع الوصف  44539.pdf pdf   الرجوع إلى صفحة الأبحاث